A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles

Authors: Carlo-Stella, N; Badulli, C; De Silvestri, A; Bazzichi, L; Martinetti, M; Lorusso, L; Bombardieri, S; Salvaneschi, L; Cuccia M

Clinical and Experimental Rheumatology, 2006

PubMed | Discussion on S4ME

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Phenotype: ME/CFS, ME/CFS - Fukuda 1994 (CDC) Criteria

IFNG, TNF

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Notes

Main finding: "There is a highly significant increase of TNF -857 TT and CT genotypes (p = 0.002) among patients with respect to controls and a significant decrease of IFN gamma low producers (A/A) (p = 0.04) among patients with respect to controls."