Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia

Authors: Wyns, Arne; Hendrix, Jolien; Van Campenhout, Jente; Buntinx, Yanthe; Xiong, Huan-Yu; De Bruyne, Elke; Godderis, Lode; Nijs, Jo; Rice, David; Chiang, Daniel; Polli, Andrea

International Journal of Molecular Sciences, 14 Jan 2026

View article | Discussion on S4ME

Cohorts in this study

Phenotype: Fibromyalgia, Fibromyalgia - ACR 2011 Criteria, ME/CFS, ME/CFS - Fukuda 1994 (CDC) Criteria

OPRM1

Search for these genes

Notes

Main finding: "Patients showed significantly higher OPRM1 promoter methylation"